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KMID : 0378019820250070059
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New Medical Journal
1982 Volume.25 No. 7 p.59 ~ p.65
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Changes of Gastric Mucosa and Serum Enzyme Concentration with Experimental Gastric Devascularization in Rat
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Abstract
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Diffuse hemorrhagic gastritis (DHG) is one of the causes of upper gastrointestinal tract bleeding and its mortality is very high due to massive bleeding.
Until recent, several surgical approaches have been performed without excellent result. Rittenhouse and Aust introduced gastric devascularization as a useful salvage procedure for the risky patients with DHG, because it could be accomplished easily, with few complications, and had low rebleed rate or permanent sequeles.
But the gastric devascularization may cause futher mucosal damage by additional ischemia, which is one of the important factors in DHG.
The author performed this experiment to investigate the serial pathological changes of gastric mucosa after gastric devascularization in normal rats.
All the experimental rats were divided into seven groups; normal, 1st day group, 3rd day group; 1st week group, 2nd week group, 3rd week group, and 4th week group after devascularization.
The author observed that histopathological changes of gastric mucosa and serum enzmes concentrations in each group. The experimental results were as follows; 1. Changes of serum enzymes;
After devascularizaton, alkaline phosphatase was markedly elevated in 1st day, 3rd day and 1st week groups than control (p<0.05).
S.G.O.T. and S.G.P.T. were elevated in 1st day and 3rd day group (p<0. 05), and normal ranges in 1st, 2nd, 3rd and 4th week groups. L.D.H. was increased throughout experimental period in all groups. (p<0.05).
2. Gross and microscopic examination of gastric mucosa.
By gross examination, diffuse, marked discoloration and edema of the gastric mucosa were noted in 1st day group.
In 3rd day, 1st week and 2nd week groups, ulcers and erosions with variable size and numbers were revealed on the gastric mucosa. In 3rd and 4th week groups, the above lesions were not noted.
Microscopically, in 1st day group, all specimens were showing, ischemic necrosis of the mucosa and acute inflammation of submucosa.
In 3rd day group, there were diffuse erosions with edematous mucosal folds in 4 rats and acute ulcers in 2 of 7 rats.
In 1st and 2nd week group, ulcerations with variable size were shown in all rats. Epithelialization of ulcer bases were noted in 4 rats of 3rd week group. In 4th week group, nearly normal mucosae were shown in all rats except one, having healing pattern of ulcer.
The above results suggest that the gastric devascularization in normal rats cause transient ischemic ulcers upto 2nd week and then recover to normal on 4th week.
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